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Rabbit Anti-CD39/FITC Conjugated antibody
background:
Members of the ecto-nucleoside triphosphate diphosphohydrolase (eNTPDase) protein family are glycosylated enzymes that hydrolyze nucleoside 5’-triphosphates and 5’-diphosphates in extracellcular space. The enzymatic activities of eNTPDase are dependent on cations such as magnesium and calcium. Members of this protein family differ in their affinities for triphosphates versus diphosphates as substrate material. CD39L3, also known as Ectonucleoside triphosphate diphosphohydrolase 3 or NTPDase 3, is a 529 amino acid multi-pass membrane protein that has a three-fold preference for hydrolysis of ATP over ADP. Both calcium and magnesium serve as cofactors for CD39L3’s extremely active extracellular nucleotide hydrolysis site. CD39L3 is expressed in spleen, prostate, brain and pancreas, though moderate to low expression is observed in most tissues, with the exception of liver and peripheral blood leukocytes.
Function:
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.
Subunit:
Homodimer; disulfide-linked (By similarity).
Subcellular Location:
Membrane; Multi-pass membrane protein (Potential).
Tissue Specificity:
Expressed primarily on activated lymphoid cells. Also expressed in endothelial tissues. Isoform 1 and isoform 3 are present in both placenta and umbilical vein, whereas isoform 2 is present in placenta only.
Post-translational modifications:
The N-terminus is blocked.
Palmitoylated in the N-terminal part.
Similarity:
Belongs to the GDA1/CD39 NTPase family.
Database links:
Entrez Gene: 953 Human
Entrez Gene: 12495 Mouse
Entrez Gene: 64519 Rat
Omim: 601752 Human
SwissProt: P49961 Human
SwissProt: P55772 Mouse
SwissProt: P97687 Rat
Unigene: 576612 Human
Unigene: 2824 Mouse
Unigene: 17491 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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