Rabbit Anti-HHV11 ICP22/FITC Conjugated antibody

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US1; Herpes simplex virus 1; Herpes Simplex Virus; Herpes Simplex Virus Type 1; HSV 1; Human herpesvirus 1; Human herpesvirus type 1; ICP22_HHV11; Transcriptional regulator ICP22; Immediate-early protein IE68; Infected cell protein 22; ICP22.

Cat:

SL15398R-FITC

Immunogen：

KLH conjugated synthetic peptide derived from human HSV1

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

46kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Herpes simplex type 1 (HSSLV1) belongs to a family that includes HSSLV2, Epstein-Barr virus (EBV) and Varicella zoster (chicken pox) virus amongst others. HSSLV1 and HSSLV2 are extremely difficult to distinguish from each other. Members of this family have a characteristic virion structure. The double stranded DNA genome is contained within an icosahedral capsid embedded in a proteinaceous layer (tegument) and surrounded by a lipid envelope, derived from the nuclear membrane of the last host, which is decorated with virus-specific glycoproteins spikes. These viruses are capable of entering a latent phase where the host shows no visible sign of infection and levels of infectious agent become very low. During the latent phase the viral DNA is integrated into the genome of the host cell.

Function:
Functions as a general transcriptional regulator of cellular and viral mRNAs mainly by mediating changes on the host RNA polymerase II. One change, which is UL13 independent, is the rapid loss of Pol II forms bearing Ser-2 phosphorylation. A second change, which is UL13 dependent, is the appearance of an intermediate form of Pol II that differs from the normal hypo- and hyperphosphorylated forms. These Pol II modifications immediately inhibit host genome transcription, leading to cell cycle deregulation and loss of efficient antiviral response.

Subcellular Location:
Host nucleus. Note=Localizes in small nuclear bodies early in infection then moves to a more diffuse distribution in viral compartments as infecion progresses.

Post-translational modifications:
Tyrosine phosphorylated.

Similarity:
Belongs to the herpesviridae IE68 family.

Database links:
Entrez Gene: 2703435 HHV11

SwissProt: P04485 HHV11

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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