background:
Helicases comprise a class of enzymes that function as motor proteins which move along nucleic acid phosphodiester bonds, effectively separating two annealed nucleic acid strands. RNA helicases alter the conformation of RNA, specifically by unwinding double-stranded RNA regions to yield single RNA strands, a process which changes the biological activity of the RNA molecule. HELZ (helicase with zinc finger), also known as DHRC or HUMORF5, is a 1,942 amino acid nuclear protein that contains one C3H1-type zinc finger and belongs to the RNA helicase superfamily. Expressed ubiquitously during embryonic development, HELZ is thought to function as an RNA helicase that modifies RNA structure and plays a role in the development of multiple organs and tissues within the developing embryo.
Function:
May act as a helicase that plays a role in RNA metabolism in multiple tissues and organs within the developing embryo.
Subunit:
Interacts with SMYD2 (By similarity). Interacts with POLR2A. Interacts with SMYD3; the interaction may bridge SMYD3 and RNA polymerase II.
Subcellular Location:
Nucleus (Probable).
Tissue Specificity:
Expressed predominantly in thymus and brain. Expression is down-regulated in 28 of 95 tested cancer cell lines.
Similarity:
Belongs to the DNA2/NAM7 helicase family.
Contains 1 C3H1-type zinc finger.
Database links:
UniProtKB/Swiss-Prot: P42694.2
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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