Rabbit Anti-HIC2 /FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-HIC2 /FITC Conjugated antibody

HIC1 related gene on chromosome 22; HIC2; Hic3; HRG22; Hypermethylated in cancer 2 protein; KIAA1020; ZBTB30; Zinc finger and BTB domain-containing protein 30; ZNF907; HIC2_HUMAN.

Cat:

SL15486R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Dog,Pig,Cow,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human HIC2

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

66kDa

prev next

Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
Feedback Wall

background:
Zinc-finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc-finger proteins contain a Krüppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. HISLC2 (hypermethylated in cancer 2) possesses zinc finger motifs that are thought to be important for DNA-binding and also has a BTB/POZ domain at the N-terminus, which is thought to be important for protein-protein binding, as well as for the binding of transcription factors. HISLC2 is also known as Hic-3, HIC1-related gene on chromosome 22 or Zinc finger and BTB domain-containing protein 30, and is a 615 amino acid protein that is expressed as two isoforms produced by alternative splicing. HISLC2 is highly expressed in cerebellum and is localized to the nucleus in cells. HISLC2 contains a short amino acid sequence that is thought to interact with CtBP, a transcriptional repressor. The gene sequence associated with HISLC2 is thought to be a target for miRNAs (microRNAs) which are expressed in many cancers, suggesting that HISLC2 could possess tumor suppressor capabilities.

Function:
Transcriptional repressor.

Subunit:
Self-associates. Interacts with HIC1.

Subcellular Location:
Nucleus.

Tissue Specificity:
Highest levels in cerebellum.

Similarity:
Belongs to the krueppel C2H2-type zinc-finger protein family. Hic subfamily.
Contains 1 BTB (POZ) domain.
Contains 5 C2H2-type zinc fingers.

Database links:

Entrez Gene: 23119 Human

Omim: 607712 Human

SwissProt: Q96JB3 Human

Unigene: 632767 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

Product Feedback Wall