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Rabbit Anti-IDO/FITC Conjugated antibody
background:
This gene encodes indoleamine 2,3-dioxygenase (IDO) – a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.
Function:
Catalyzes the cleavage of the pyrrol ring of tryptophan and incorporates both atoms of a molecule of oxygen.
Similarity:
Belongs to the indoleamine 2,3-dioxygenase family.
Database links:
Entrez Gene: 3620 Human
Entrez Gene: 15930 Mouse
Entrez Gene: 66029 Rat
Omim: 147435 Human
SwissProt: P14902 Human
SwissProt: P28776 Mouse
SwissProt: Q9ERD9 Rat
Unigene: 168 Human
Unigene: 392 Mouse
Unigene: 64513 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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