Rabbit Anti-FGFR substrate 3/FITC Conjugated antibody

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FGFR signalling adaptor SNT2; FGFR substrate 3; Fibroblast growth factor receptor substrate 3; FRS2 beta; FRS2B; FRS3; FRS3 protein; MGC17167; SNT 2; Suc1 associated neurotrophic factor target 2 (FGFR signalling adaptor); Suc1 associated neurotrophic fact

Cat:

SL10383R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Cow,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human FGFR substrate 3

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

54kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The protein encoded by this gene is a substrate for the fibroblast growth factor receptor. It is found in peripheral plasma membrane and functions in linking FGF receptor stimulation to activators of Ras. [provided by RefSeq, Jul 2008].

Function:
Adapter protein that links FGF and NGF receptors to downstream signaling pathways. Involved in the activation of MAP kinases. Down-regulates ERK2 signaling by interfering with the phosphorylation and nuclear translocation of ERK2.

Subunit:
Binds NTRK1. Binds FGFR1, NGFR, GRB2, PTPN11 and ERK2.

Subcellular Location:
Membrane; Lipid-anchor.

Tissue Specificity:
Phosphorylated by ULK2 in vitro. Phosphorylated on tyrosine residues upon stimulation by SFGF or NGFB.

Similarity:
Contains 1 IRS-type PTB domain.

Database links:

Entrez Gene: 10817 Human

Entrez Gene: 107971 Mouse

Entrez Gene: 316213 Rat

Omim: 607744 Human

SwissProt: O43559 Human

SwissProt: Q91WJ0 Mouse

SwissProt: Q52RG8 Rat

Unigene: 194208 Human

Unigene: 34398 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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