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Rabbit Anti-Thrombopoietin/FITC Conjugated antibody
background:
Megakaryocytopoiesis is the cellular development process that leads to platelet production. The protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene. Mutations in this gene are the cause of thrombocythemia 1. Alternate splicing results in multiple transcript variants of this gene.[provided by RefSeq, Jun 2012].
Function:
Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
Subcellular Location:
Secreted.
DISEASE:
Thrombocythemia 1 (THCYT1) [MIM:187950]: A myeloproliferative disorder characterized by excessive platelet production, resulting in increased numbers of circulating platelets. It can be associated with spontaneous hemorrhages and thrombotic episodes. Note=The disease is caused by mutations affecting the gene represented in this entry.
Similarity:
Belongs to the EPO/TPO family.
Database links:
Entrez Gene: 7066 Human
Entrez Gene: 21832 Mouse
Entrez Gene: 81811 Rat
Omim: 600044 Human
SwissProt: P40225 Human
SwissProt: P40226 Mouse
SwissProt: P49745 Rat
Unigene: 1166 Human
Unigene: 3943 Mouse
Unigene: 10576 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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