Rabbit Anti-CLCA4/FITC Conjugated antibody

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CaCC-2; Calcium-activated chloride channel family member 4; Calcium-activated chloride channel protein 2; Calcium-activated chloride channel regulator 4; Clca4; CLCA4_HUMAN; hCaCC-2; hCLCA4; calcium-activated chloride channel regulator 4 precursor; Partur

Cat:

SL15511R-FITC

Species Reactivity：

Rat,(predicted: Human,Mouse,Dog,Pig,Cow,Horse,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human CLCA4

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

99、101kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Alternative splicing results in multiple transcript variants, only one of which is thought to be protein coding. [provided by RefSeq, Dec 2008].

Function:
May be involved in mediating calcium-activated chloride conductance.

Subcellular Location:
Cell membrane; Single-pass membrane protein. Apical cell membrane. Secreted. Note=The SLCterminus 30 kDa form is anchored to the membrane. The N-terminus 110 kDa form is released from the membrane triggered by an unknown stimulus. Associated with the microvilli of non-goblet cell enterocytes in the small and large intestine. Co-localizes with CFTR.

Tissue Specificity:
Expressed in the non-goblet intestinal cells. High levels in intestine and stomach, and lower levels in eye, liver and spleen. Increasing expression from the duodenum to the ilium, and decreasing expression to the colon. Isoform 2 is expressed in intestine and stomach but at lower levels than isoform 1.

Post-translational modifications:
N-Glycosylated.
Processed at a monobasic residue to yield a larger N-terminal and a smaller SLCterminal cleavage products of 90 to 110 and 30 to 35 kDa, respectively.

Similarity:
Belongs to the CLCR family.
Contains 1 VWFA domain.

Database links:

Entrez Gene: 22802 Human

SwissProt: Q14CN2 Human

Unigene: 567422 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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