background:
The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq, Oct 2009]
Function:
Chemotactic for eosinophils and basophils. Binds to CCR3.
Subunit:
Monomer.
Subcellular Location:
Secreted.
Tissue Specificity:
Ubiquitously expressed at low levels in various tissues including heart and ovary.
Similarity:
Belongs to the intercrine beta (chemokine CC) family.
Database links:
Entrez Gene: 10344 Human
Entrez Gene: 541307 Mouse
Omim: 604697 Human
SwissProt: Q9Y258 Human
Unigene: 131342 Human
Unigene: 376459 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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