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Rabbit Anti-HINT1/FITC Conjugated antibody
background:
The protein encoded by this gene can hydrolyze substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester, and AMP-NH2. The encoded protein interacts with these substrates via a histidine triad motif, which is part of the loop that binds to the substrate. This gene has been found to be a tumor suppressing gene. Several transcript variants, but only one of them protein-coding, have been found for this gene. [provided by RefSeq, Dec 2012].
Function:
Hydrolyzes adenosine 5'-monophosphoramidate substrates such as AMP-morpholidate, AMP-N-alanine methyl ester, AMP-alpha-acetyl lysine methyl ester and AMP-NH2.
Subunit:
Homodimer. Interacts with CDK7.
Subcellular Location:
Cytoplasm. Nucleus. Note=Interaction with CDK7 leads to a more nuclear localization.
Tissue Specificity:
Widely expressed.
Similarity:
Belongs to the HINT family.
Contains 1 HIT domain.
Database links:
Entrez Gene: 3094 Human
Entrez Gene: 15254 Mouse
Entrez Gene: 690660 Rat
Omim: 601314 Human
SwissProt: P49773 Human
SwissProt: P70349 Mouse
SwissProt: P62959 Rat
Unigene: 483305 Human
Unigene: 425 Mouse
Unigene: 138667 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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