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Home > Product > Antibody > Rabbit Anti-ICK/FITC Conjugated antibody
2210420N10Rik; AI848300; ECO; ICK_HUMAN; Heart serine threonine protein kinase; hICK; Intestinal cell (MAK like) kinase; Intestinal cell kinase; KIAA0936; Laryngeal cancer kinase 2; LCK2; MAK-related kinase; MAK related kinase; MGC46090; mICK; MRK; OTTMUS
Cat:
SL15536R-FITC
Species Reactivity：
(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,)
Immunogen：
KLH conjugated synthetic peptide derived from human ICK
Format：
Lyophilized or Liquid
Storage instructions：
Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant
Buffer：
0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
Concentration：
1mg/ml
Clonality：
Polyclonal
Isotype：
IgG
Applications：
ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.
Host：
Rabbit
Calculated MW：
71kDa
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Product PDFs
Datasheet:


background:
Eukaryotic protein kinases are enzymes that belong to a very extensive family of proteins which share a conserved catalytic core common with both serine/threonine and tyrosine protein kinases. This gene encodes an intestinal serine/threonine kinase harboring a dual phosphorylation site found in mitogen-activating protein (MAP) kinases. The protein localizes to the intestinal crypt region and is thought to be important in intestinal epithelial cell proliferation and differentiation. Alternative splicing has been observed at this locus and two variants, encoding the same isoform, have been identified.

Function:
May play a key role in the development of multiple organ systems and particularly in cardiac development.

Subcellular Location:
Nucleus. Cytoplasm, cytosol. Note=Nuclear localization has been observed with a GFP-tagged construct in transfected HeLa cells (PubMed:1210372). Cytosolic localization was shown in rat embryonic cardiomyocytes by immunostaining (PubMed:8570168).

Tissue Specificity:
Expressed in heart, brain, placenta, pancreas, thymus, prostate, testis, ovary, small intestine and colon, with highest levels in placenta and testis. Not detected in spleen. Also expressed in many cancer cell lines.

Post-translational modifications:
Autophosphorylated on serine and threonine residues. May play a role in enzyme activation.

DISEASE:
Endocrine-cerebroosteodysplasia (ECO) [MIM:612651]: Previously unidentified neonatal lethal recessive disorder with multiple anomalies involving the endocrine, cerebral, and skeletal systems. Note=The disease is caused by mutations affecting the gene represented in this entry.

Similarity:
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.
Contains 1 protein kinase domain.

Database links:

Entrez Gene: 22858 Human

Entrez Gene: 56542 Mouse

Entrez Gene: 84411 Rat

Omim: 612325 Human

SwissProt: Q9UPZ9 Human

SwissProt: Q9JKV2 Mouse

SwissProt: Q62726 Rat

Unigene: 417022 Human

Unigene: 288719 Mouse

Unigene: 3750 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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