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Rabbit Anti-IBP160/FITC Conjugated antibody
background:
Intron-binding spliceosomal protein required to link pre-mRNA splicing and snoRNP (small nucleolar ribonucleoprotein) biogenesis. Plays a key role in position-dependent assembly of intron-encoded box C/D small snoRNP, splicing being required for snoRNP assembly. May act by helping the folding of the snoRNA sequence. Binds to intron of pre-mRNAs in a sequence-independent manner, contacting the region between snoRNA and the branchpoint of introns (40 nucleotides upstream of the branchpoint) during the late stages of splicing.
Subunit:
Identified in the spliceosome C complex.
Subcellular Location:
Nucleus. Note=Localizes to speckle-like regions of the nucleoplasm.
Similarity:
Belongs to the CWF11 family.
Database links:
Entrez Gene: 9716 Human
Omim: 610548 Human
SwissProt: O60306 Human
Unigene: 510958 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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