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Rabbit Anti-IFNA14/FITC Conjugated antibody
background:
The genes encoding type I interferons (IFNs), which include 14 IFN-alpha genes, 1 IFN-beta gene, 1 IFN-omega (also known as IFN-alpha II1) gene, and a number of IFN-omega pseudogenes, are clustered on human chromosome 9. Interferon-alpha and -beta are cytokines that are widely known to induce potent antiviral activity. They exert a variety of other biological effects, including antitumor and immunomodulatory activities and are increasingly used clinically to treat a range of malignancies, myelodysplasias and autoimmune diseases. IFN-omega is antigenically different from human IFN-alpha, IFN-beta or IFN-gamma, but is a component of natural mixtures of IFN species produced by virus-induced leukocytes or Burkitt's lymphoma cells. The type I interferon receptor (IFN-alpha R) interacts with IFN-alpha, IFN-beta and IFN-omega, and seems to be a multisubunit receptor.
Function:
Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
Subcellular Location:
Secreted.
Similarity:
Belongs to the alpha/beta interferon family.
Database links:
Entrez Gene: 3448 Human
Omim: 147579 Human
SwissProt: P01570 Human
Unigene: 93907 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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