Home
>
Product
>
Antibody
>
Rabbit Anti-IDI2/FITC Conjugated antibody
background:
IDI2 is a 227 amino acid protein that belongs to the IPP isomerase type 1 family. Localizing to the peroxisome, IDI2 is expressed in skeletal muscle and contains one nudix hydrolase domain. IDI2 utilizes magnesium as a cofactor and participates in isoprenoid biosythesis. IDI2 catalytically converts isopentenyl diphosphate (IPP) to its electrophilic isomer, dimethylallyl diphosphate (DMAPP), a substrate for subsequent reactions that synthesize farnesyl diphosphate and, ultimately, cholesterol. The gene encoding IDI2 maps to human chromosome 10p15.3. Segmental copy-number gains to the IDI2 gene may contribute to the pathogenesis of sporadic amyotrophic lateral sclerosis (SALS). SALS, also known as Lou Gehrig's disease, is a motor neuron disease characterized by neuron degeneration
Function:
Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).
Subcellular Location:
Peroxisome.
Tissue Specificity:
Detected in skeletal muscle.
Similarity:
Belongs to the IPP isomerase type 1 family.
Contains 1 nudix hydrolase domain.
Database links:
Entrez Gene: 91734 Human
Entrez Gene: 64581 Mouse
Entrez Gene: 502143 Rat
SwissProt: Q9BXS1 Human
SwissProt: Q4FZF0 Mouse
Unigene: 591325 Human
Unigene: 9270 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|