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Rabbit Anti-FUT5/FITC Conjugated antibody
background:
The protein encoded by this gene belongs to the glycosyltransferase family. It is localized to the golgi, and catalyzes the last step in the biosynthesis of Lewis X (LeX) antigen, the addition of a fucose to precursor polysaccharides. This protein is one of the few fucosyltransferases that synthesizes the LeX oligosaccharide (CD15) expressed in the organ buds progressing in mesenchyma during embryogenesis. It is also responsible for the expression of CD15 in mature granulocytes. A common haplotype of this gene has also been associated with susceptibility to placental malaria infection. [provided by RefSeq, Nov 2011]
Function:
May catalyze alpha-1,3 glycosidic linkages involved in the expression of VIM-2, Lewis X/SSEA-1 and sialyl Lewis X antigens.
Subcellular Location:
Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi.
Tissue Specificity:
Liver, colon and testis and trace amounts in T-cells and brain.
Similarity:
Belongs to the glycosyltransferase 10 family.
Database links:
Entrez Gene: 10690 Human
Entrez Gene: 2526 Human
Entrez Gene: 2527 Human
Entrez Gene: 2528 Human
Entrez Gene: 2529 Human
Omim: 136835 Human
SwissProt: P22083 Human
SwissProt: P51993 Human
SwissProt: Q11128 Human
SwissProt: Q11130 Human
SwissProt: Q9Y231 Human
Unigene: 390420 Human
Unigene: 457 Human
Unigene: 49117 Human
Unigene: 572064 Human
Unigene: 623098 Human
Unigene: 631843 Human
Unigene: 631846 Human
Unigene: 705615 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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