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Rabbit Anti-IFT81/FITC Conjugated antibody
background:
IFT81 is a 676 amino acid protein that is present at high levels in testis and is moderately expressed in heart, liver, ovary, pancreas, kidney and skeletal muscle. Existing as three alternatively spliced isoforms, two of which are designated CDSLV1 and CDSLV1R, IFT81 plays a role in testicular development and spermatogenesis and may also be involved in cardiac hypertrophy caused by carnitine deficiency. The gene encoding IFT81 maps to human chromosome 12, which encodes over 1,100 genes and comprises approximately 4.5% of the human genome. Chromosome 12 is associated with a variety of diseases and afflictions, including hypochondrogenesis, achondrogenesis, Kniest dysplasia, Noonan syndrome and Trisomy 12p, which causes facial developmental defects and seizure disorders.
Function:
Isoform CDSLV1 may be involved in cardiac hypertrophy caused by carnitine deficiency (By similarity).
Isoform CDSLV1R appears to play a role in development of the testis and spermatogenesis (By similarity).
Tissue Specificity:
Highly expressed in testis, moderately in ovary, heart, liver, skeletal muscle, kidney and pancreas, low in prostate, brain, placenta and lung and not detected in spleen, thymus, small intestine and colon. Isoform CDSLV1R is abundantly expressed in testis.
Database links:
Entrez Gene: 28981 Human
SwissProt: Q8WYA0 Human
Unigene: 528382 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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