background:
IFT20 is a gene encodes a intraflagellar transport protein important for intracellular transport. The encoded protein forms part of a complex involved in trafficking of proteins from the Golgi body, including recycling of immune signalling components (Finetti et al., PubMed: 19855387). This gene is part of a complex set of sense-antisense loci that may be co-regulated. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome 14.
Function:
Part of intraflagellar transport (IFT) particles involved in ciliary process assembly. May play a role in the trafficking of ciliary membrane proteins from the Golgi complex to the cilium.
Subunit:
Component of IFT complex B composed of IFT88, IFT57, TRAF3IP1, IFT52, IFT27, HSPB11 and IFT20. Interacts directly with IFT57 and KIF3B/Kinesin II subunit (By similarity). Interacts with CCDC41/CEP83.
Subcellular Location:
Golgi apparatus, cis-Golgi network (By similarity). Cytoplasm, cytoskeleton, centrosome, centriole (By similarity). Cytoplasm, cytoskeleton, cilium basal body (By similarity). Note=Present at the centrosomes during the cell cycle and associated with the proximal portion of the mother centriole and the lateral aspect of the daughter centriole. Associated with basal body at the base of primary cilia (By similarity).
Tissue Specificity:
Expressed in almost all tissues.
Database links:
UniProtKB/Swiss-Prot: Q8IY31.1
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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