background:
The genes encoding type I interferons (IFNs), which include 14 IFN-alpha genes, 1 IFN-beta gene, 1 IFN-gamma (also known as IFN-alphaII1) gene, and a number of IFN-gamma pseudogenes, are clustered on human chromosome 9. Interferons-alpha and -beta are cytokines that are widely known to induce potent antiviral activity. IFN-alpha and -beta exert a variety of other biological effects, including anti-tumor and immunomodulatory activities, and are increasingly used clinically to treat a range of malignancies, myelodysplasias and autoimmune diseases.
Subcellular Location:
Secreted (Potential).
Tissue Specificity:
Expressed in prostate cancer cell line PSLC3, amnion-derived WISH cells, melanoma cell line SK-MEL-28, cell line Daudi and very weakly in MCF-7 human breast cancer cells. Not detected in cell lines Namalwa (Burkitt's lymphoma) and Jurkat (T-cell).
Similarity:
Belongs to the alpha/beta interferon family.
Database links:
Entrez Gene: 338376 Human
SwissProt: Q86WN2 Human
Unigene: 682604 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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