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Rabbit Anti-DYNC1I2/FITC Conjugated antibody
background:
The inner- and outer-arm dyneins, which bridge between the doublet microtubules in axonemes, are the force-generating proteins responsible for the sliding movement in axonemes. The intermediate and light chains, thought to form the base of the dynein arm, help mediate attachment and may also participate in regulating dynein activity. This gene encodes an intermediate chain dynein, belonging to the large family of motor proteins. Mutations in this gene result in abnormal ciliary ultrastructure and function associated with primary ciliary dyskinesia (PCD) and Kartagener syndrome. [provided by RefSeq, Jul 2008].
Function:
Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes.
Subunit:
Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. Interacts with DYNLT1 and DYNLT3. Interacts with DCNT1. Interacts with human adenovirus 5 hexon protein; this interaction probably allows virus intracellular transport.
Subcellular Location:
Cytoplasm, cytoskeleton.
Post-translational modifications:
The phosphorylation status of Ser-90 appears to be involved in dynactin-dependent target binding.
Similarity:
Belongs to the dynein intermediate chain family.
Contains 7 WD repeats.
Database links:
Entrez Gene: 1781 Human
Entrez Gene: 13427 Mouse
Entrez Gene: 116659 Rat
Omim: 603331 Human
SwissProt: Q13409 Human
SwissProt: O88487 Mouse
SwissProt: Q62871 Rat
Unigene: 546250 Human
Unigene: 249479 Mouse
Unigene: 11014 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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