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Rabbit Anti-FoxP3/FITC Conjugated antibody
background:
The protein encoded by this gene is a member of the forkhead/winged-helix family of transcriptional regulators. Defects in this gene are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX), also known as X-linked autoimmunity-immunodeficiency syndrome. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
Function:
Probable transcription factor. Plays a critical role in the control of immune response.
Subunit:
Interacts with IKZF3.
Subcellular Location:
Nucleus (Potential).
Post-translational modifications:
Acetylation on lysine residues stabilizes FOXP3 and promotes differentiation of T-cells into induced regulatory T-cells (iTregs) associated with suppressive functions. Deacetylated by SIRT1.
DISEASE:
Defects in FOXP3 are the cause of immunodeficiency polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) [MIM:304790]; also known as X-linked autoimmunity-immunodeficiency syndrome. IPEX is characterized by neonatal onset insulin-dependent diabetes mellitus, infections, secretory diarrhea, trombocytopenia, anemia and eczema. It is usually lethal in infancy.
Similarity:
Contains 1 C2H2-type zinc finger.
Contains 1 fork-head DNA-binding domain.
Database links:
Entrez Gene: 50943 Human
Entrez Gene: 20371 Mouse
Entrez Gene: 317382 Rat
Omim: 300292 Human
SwissProt: Q9BZS1 Human
SwissProt: Q99JB6 Mouse
SwissProt: D3ZKI1 Rat
Unigene: 247700 Human
Unigene: 182291 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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