background:
AFM is a member of the albumin gene family, which is comprised of four genes that localize to chromosome 4 in a tandem arrangement. These four genes encode structurally-related serum transport proteins that are known to be evolutionarily related. The protein encoded by this gene is regulated developmentally, expressed in the liver and secreted into the bloodstream.
Function:
Vitamin E binding protein. May transport vitamin E in body fluids under conditions where the lipoprotein system is not sufficient. May be involved in the regulation and transport of vitamin E at the blood-brain barrier (By similarity).
Subcellular Location:
Secreted.
Tissue Specificity:
High level detected in plasma but also in extravascular fluids such as follicular and cerebrospinal fluids (at protein level).
Post-translational modifications:
N-glycosylated; more than 90% of the glycans are sialylated.
Similarity:
Belongs to the ALB/AFP/VDB family.
Contains 3 albumin domains.
Database links:
Entrez Gene: 173 Human
Entrez Gene: 280662 Mouse
Entrez Gene: 282708 Rat
Omim: 104145 Human
SwissProt: P43652 Human
SwissProt: O89020 Mouse
SwissProt: P36953 Rat
Unigene: 168718 Human
Unigene: 348786 Mouse
Unigene: 214035 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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