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Rabbit Anti-OAS3/FITC Conjugated antibody
background:
The 2'- 5'- oligoadenylate synthetase (OAS) family is comprised of four members: OAS1, OAS2, OAS3 and OASL. These proteins are induced by interferons and function to convert ATP into 2'- 5'- linked oligomers of adenosine in the presence of double-stranded RNA and magnesium ions. Copper, iron and zinc ions strongly inhibit the OAS enzymatic activity, while manganese ions can replace magnesium ions as an activator. The OAS family plays a significant role in the inhibition of cellular protein synthesis, apoptosis and growth, and its members are important factors in viral infection resistance. OAS3, also referred to as p100, contains three adjacent OAS1-like domains and maps to the human chromosome 12q24.2
Function:
May play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. OAS3 synthesizes preferentially dimeric 2',5'-oligoadenylate molecules. GTP can be an alternative substrate.
Tissue Specificity:
Present at high level in placenta trophoblast.
Similarity:
Belongs to the 2-5A synthase family.
Database links:
Entrez Gene: 4940 Human
Omim: 603351 Human
SwissProt: Q9Y6K5 Human
Unigene: 528634 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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