Rabbit Anti-TBX3/FITC Conjugated antibody

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T-box protein 3; T-box transcription factor TBX3; TBX3; TBX3-ISO; TBX3 ISO; UMS; XHL; Bladder cancer related protein XHL; T box 3; TBX3_HUMAN.

Cat:

SL10266R-FITC

Species Reactivity：

Mouse,(predicted: Human,Rat,Dog,Pig,Cow,Horse,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human TBX3

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

82kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Tbx3 gene is a member of a phylogenetically conserved family of genes that share a common DNA binding domain, the T box. T box genes encode transcription factors involved in the regulation of developmental processes. Tbx3 is a transcriptional repressor and is thought to play a role in the anterior/posterior axis of the tetrapod forelimb. Mutations in this gene cause ulnar mammary syndrome, affecting limb, apocrine gland, tooth, hair, and genital development. Alternative splicing of this gene results in three transcript variants encoding different isoforms; however, the full length nature of one variant has not been determined.

Function:
Transcriptional repressor involved in developmental processes. Probably plays a role in limb pattern formation.

Subcellular Location:
Nucleus (Potential).

Tissue Specificity:
Widely expressed.

DISEASE:
Defects in TBX3 are the cause of ulnar-mammary syndrome (UMS) [MIM:181450]. UMS is characterized by ulnar ray defects, obesity, hypogenitalism, delayed puberty, hypoplasia of nipples and apocrine glands.

Similarity:
Contains 1 T-box DNA-binding domain.

Database links:

Entrez Gene: 6926 Human

Entrez Gene: 21386 Mouse

Entrez Gene: 353305 Rat

Omim: 601621 Human

SwissProt: O15119 Human

SwissProt: P70324 Mouse

SwissProt: Q7TST9 Rat

Unigene: 129895 Human

Unigene: 219139 Mouse

Unigene: 162144 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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