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Rabbit Anti-DLG5/FITC Conjugated antibody
background:
Membrane-associated guanylate kinase (MAGUK) family members function as molecular scaffolds for the assembly of multiprotein complexes localizing to the plasma membrane. Several mammalian proteins related to the Drosophila tumor suppressor discs-large (dlg) gene product belong to the MAGUK family. MAGUK family members include the postsynaptic proteins PSD-93, DLG5, Pals1, PSD-95 (SAP 90), densin-36, NE-dlg (SAP 120), dlg-1 (SAP 97), GKAP (GK-associated protein), p55, the tight junction associated proteins ZO-1-3 and the caspase-associated recruitment domain (CARD) proteins CARD6, CARD8-12 and CARD14. DLG5, a cell-cell junction peripheral membrane protein, plays an important role in maintaining the structure of epithelial cell plasma membranes. It also plays an important part in transmitting extracellular signals to the cytoskeleton and the membrane. DLG5 which can interact with MPP1 and CTNNB1, is primarily expressed in prostate and placenta.
Function:
May play a role at the plasma membrane in the maintenance of the structure of epithelial cells and in the transmission of extracellular signals to the membrane and cytoskeleton.
Subcellular Location:
Cell junction. Cell membrane. Localized at sites of cell-cell contact.
Tissue Specificity:
Highly expressed in the placenta and prostate. Expressed at a lower level in the thyroid, spinal cord, trachea, adrenal gland, skeletal muscle, pancreas, heart, brain, liver and kidney. A short splice product shows more limited expression, being absent from at least the brain.
Similarity:
Belongs to the MAGUK family.
Contains 1 CARD domain.
Contains 1 guanylate kinase-like domain.
Contains 4 PDZ (DHR) domains.
Contains 1 SH3 domain.
Database links:
Entrez Gene: 9231 Human
Entrez Gene: 71228 Mouse
Entrez Gene: 305645 Rat
Omim: 604090 Human
SwissProt: Q8TDM6 Human
Unigene: 652690 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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