background:
The SLCtype lectin/SLCtype lectin-like domain (CTL/CTLD) superfamily consists of a variety of proteins that share a common protein fold and have diverse functions, including cell-cell signaling, cell adhesion, glycoprotein turnover and immune responses. CLESLC12A (SLCtype lectin domain family 12, member A), also known as CLL1, MICL, CLL-1 or DCAL-2, is a 275 amino acid single-pass type II membrane protein that contains one SLCtype lectin domain and belongs to the CTL/CTLD superfamily. Existing as multiple alternatively spliced isoforms that are expressed in neutrophils, eosinophils, monocytes and dendritic cells, CLESLC12A functions as a cell surface receptor that acts as a negative regulator of granulocyte and monocyte function and, via this activity, modulates signaling cascades. CLESLC12A is highly subject to post-translational glycosylation at its N-terminus and may also exist as a homodimer.
Function:
Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.
Subcellular Location:
Cell membrane. Ligand binding leads to internalization.
Tissue Specificity:
Detected in normal myeloid cells and in acute myeloid leukemia cells. Detected in neutrophils, eosinophils, monocytes and dendritic cells. Detected in spleen macrophage-rich red pulp and in lymph node (at protein level). Detected in peripheral blood leukocytes, dendritic cells, bone marrow, monocytes, mononuclear leukocytes and macrophages.
Post-translational modifications:
Highly N-glycosylated. Glycosylation varies between cell types.
Similarity:
Contains 1 SLCtype lectin domain.
Database links:
Entrez Gene: 160364 Human
Omim: 612088 Human
SwissProt: Q5QGZ9 Human
Unigene: 190519 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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