Rabbit Anti-CED6/FITC Conjugated antibody

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CED 6; Cell death protein 6 homolog; Engulfment adapter protein; Engulfment adaptor PTB domain containing 1; GULP; GULP, engulfment adaptor PTB domain containing 1; GULP1; GULP1_HUMAN; Protein GULP; PTB domain adapter protein CED 6; PTB domain a

Cat:

SL13626R-FITC

Species Reactivity：

(predicted: Human,Mouse,Pig,Cow,Horse,Rabbit,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human CED6

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

34kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Several proteins involved in regulating and executing programmed cell death have been identified in C. elegans. CED-3, a member of the ICE protease/caspase family, and CED-4, a homolog of the mammalian Apaf-1, promote apoptosis. CED-9, a homolog of the mammalian Bcl-2 protein, inhibits cell death. EGL-1 and CED-6 both function as death-promoting proteins, with CED-6 playing a role in the engulfment of apoptotic cells. CED-5 and CED-7 are C. elegans orthologs of the mammalian DOCK36 and ABC transporter proteins, respectively, and also play a role in the engulfment of dying cells.

Function:
May function as an adapter protein. Required for efficient phagocytosis of apoptotic cells. Modulates cellular glycosphingolipid and cholesterol transport. May play a role in the internalization and endosomal trafficking of various LRP1 ligands, such as PSAP. Increases cellular levels of GTP-bound ARF6.

Subcellular Location:
Cytoplasm. May associate with the cytoplasmic side of the plasma membrane and early endosomes.

Tissue Specificity:
Widely expressed. Detected in macrophages, pancreas, kidney, skeletal muscle, heart, colon, intestine, lung, placenta and ovary.

Similarity:
Belongs to the ced-6 family.
Contains 1 PID domain.

Database links:

Entrez Gene: 51454 Human

Entrez Gene: 70676 Mouse

Entrez Gene: 314543 Rat

Omim: 608165 Human

SwissProt: Q9UBP9 Human

SwissProt: Q8K2A1 Mouse

SwissProt: Q5PQS4 Rat

Unigene: 470887 Human

Unigene: 712910 Human

Unigene: 133132 Mouse

Unigene: 32649 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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