Rabbit Anti-CD53/FITC Conjugated antibody

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AI323659; Antigen MOX44 identified by monoclonal; MRC-OX44; CD 53; CD53; CD53 antigen; CD53 antigen, isoform CRA_b; CD53 glycoprotein; Cd53 molecule; CD53 tetraspan antigen; CD53_HUMAN; Cell surface glycoprotein CD53; Leukocyte antigen MRC OX-44; Leukocyt

Cat:

SL13625R-FITC

Species Reactivity：

(predicted: Human,)

Immunogen：

KLH conjugated synthetic peptide derived from human CD53

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

24kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The CD53 antigen is a member of the tetraspanin membrane protein family that is expressed in the lymphoid-myeloid lineage. The tetraspanin superfamily (CD9, CD37, CD53, CD63, CD81 and CD82) comprises a group of cell-surface proteins that are involved in cell activation and signal transduction as well as in cell adhesion, motility and metastasis. Tetraspanin transmembrane proteins have a metastasis suppressor effect by acting as cell motility brakes in tumor cells. Human neutrophils express high levels of CD53, an N-glycosylated pan-leukocyte antigen and the true homolog of the rat MRSLCOX-44 antigen. CD53 is expressed on B cells, monocytes, macrophages, neutrophils, single (CD4 or CD8) positive thymocytes and peripheral T cells.

Function:
Required for efficient formation of myofibers in regenerating muscle at the level of cell fusion. May be involved in growth regulation in hematopoietic cells (By similarity).

Subunit:
Interacts with SCIMP.

Subcellular Location:
Membrane.

Tissue Specificity:
B-cells, monocytes, macrophages, neutrophils, single (CD4 or CD8) positive thymocytes and peripheral T-cells.

Similarity:
Belongs to the tetraspanin (TM4SF) family.

Database links:

Entrez Gene: 963 Human

Omim: 151525 Human

SwissProt: P19397 Human

Unigene: 443057 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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