background:
AHNAK is a 5,890 amino acid protein encoded by the human gene AHNAK. The intronless AHNAK gene is located on human chromosome 11q12 and has three main structural regions: the 251 amino acid N-terminus, a large central region of 4390 amino acids with multiple repeated units of about 128 amino acids in length, and the 1002 amino acid SLCterminus. The central region seems to have antiparallel beta-strands connected by intervening loops. Several putative regulatory elements are clustered within the SLCterminal region, including nuclear export localization signals, a leucine zipper, and potential phosphorylation sites for Akt1 and PKC. AHNAK is believed to be an important signalling molecule involved in a wide range of physiological activities and may be required for neuronal cell differentiation.. AHNAK also appears to influence b-adrenergic regulation of cardiac L-type Ca2+ channel function.
Function:
May be required for neuronal cell differentiation.
Subunit:
Interacts with DYSF; the interaction is direct and Ca(2+)-independent.
Subcellular Location:
Nucleus.
Similarity:
Contains 1 PDZ (DHR) domain.
Database links:
Entrez Gene: 79026 Human
Entrez Gene: 66395 Mouse
Entrez Gene: 191572 Rat
Entrez Gene: 73762 Rhesus monkey
Omim: 103390 Human
SwissProt: Q09666 Human
Unigene: 502756 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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