Rabbit Anti-HSH2D/FITC Conjugated antibody

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Adaptor in lymphocytes of unknown function X; ALX; FLJ14886; hematopoietic SH2 domain containing; Hematopoietic SH2 domain containing protein; Hematopoietic SH2 domain-containing protein; Hematopoietic SH2 protein; HSH2; Hsh2d; HSH2D_HUMAN.

Cat:

SL13643R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Cow,Horse,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human HSH2D

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

39kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
HSH2 is a 352 amino acid nuclear and cytoplasmic protein that is predominantly expressed in spleen and hematopoietic cells, such as peripheral blood leukocytes, and weakly expressed in prostate, thymus, heart, small intestine and placenta. Containing an SH2 domain, four PXXP polyproline sequences and two possible tyrosine phosphorylation sites, HSH2 interacts with tyrosine kinases Fes and ACK. Considered an adaptor protein, HSH2 participates in tyrosine kinase signaling and may be involved in the regulation of cytokine signaling and cytoskeletal reorganization in hematopoietic cells. HSH2 may also act to attenuate apoptosis through modulating the apoptotic response by promoting mitochondrial stability. HSH2 exists as two alternatively spliced isoforms and is encoded by a gene located on human chromosome 19p13.11.

Function:
May be a modulator of the apoptotic response through its ability to affect mitochondrial stability (By similarity). Adapter protein involved in tyrosine kinase and CD28 signaling. Seems to affect CD28-mediated activation of the RE/AP element of the interleukin-2 promoter.

Subcellular Location:
Cytoplasm. Nucleus.

Tissue Specificity:
Predominantly expressed in spleen and hematopoietic cells such as peripheral blood leukocytes and weakly expressed in prostate, thymus, heart, small intestine and placenta.

Post-translational modifications:
May be phosphorylated by FES and ACK1.

Similarity:
Contains 1 SH2 domain.

Database links:

Entrez Gene: 84941 Human

Omim: 608349 Human

SwissProt: Q96JZ2 Human

Unigene: 631617 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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