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Rabbit Anti-LILRB2/FITC Conjugated antibody
background:
Leukocyte immunoglobulin-like receptors (LIRs) are members of the immunoglobulin superfamily of glycoproteins and are predominantly expressed by monocytes, B cells, dendritic cells, natural killer (NK) cells, peripheral blood leukocytes and tissues such as placenta, lung and liver. These receptors all contain a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM), have an inhibitory function and are type I membrane proteins. When they bind to MHC (or other ligands) and ITIM is tyrosine phosphorylated, protein-tyrosine phosphatases are recruited and an inhibitory signal cascade triggered. ILT-4, also designated LIR-2, MIR-10 or CD85D antigen, competes with CD8A for binding to class I MHC antigens.
Function:
Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.
Subcellular Location:
Membrane.
Tissue Specificity:
Expressed on monocytes and B-cells, and at lower levels on dendritic cells. Detected at low levels in natural killer (NK) cells.
Post-translational modifications:
Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6.
Similarity:
Contains 4 Ig-like C2-type (immunoglobulin-like) domains.
Database links:
Entrez Gene: 10288 Human
Omim: 604815 Human
SwissProt: Q8N423 Human
Unigene: 655652 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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