Rabbit Anti-LNK/FITC Conjugated antibody

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IDDM20; Lymphocyte adapter protein; Lymphocyte specific adapter protein; Lymphocyte specific adapter protein Lnk; Lymphocyte-specific adapter protein Lnk; SH2B adapter protein 3; SH2B adaptor protein 3; Sh2b3; SH2B3_HUMAN; Signal transduction protein Lnk.

Cat:

SL13651R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Cow,Horse,Sheep,Monkey,)

Immunogen：

KLH conjugated synthetic peptide derived from human LNK

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

63kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
APS (adapter molecule containing PH and SH2 domains), SH2-B and Lnk compose a family of adapter proteins, which contain a pleckstrin homology (PH) domain, an SH2 domain and a tyrosine phosphorylation site. Stimulation of B cell receptor (BCR) or T cell receptor (TCR) results in the phosphorylation of the immunoreceptor tyrosine-based activation motif (ITAM) of BCR, TCR and several substrates. APS, SH2-B and Lnk may bind to the ITAM domain of BCR and TCR. Lnk is tyrosine phosphorylated in response to TCR stimulation and APS has been shown to be tyrosine phosphorylated in response to BCR stimulation.

Function:
Links T-cell receptor activation signal to phospholipase SLCgamma-1, GRB2 and phosphatidylinositol 3-kinase.

Tissue Specificity:
Preferentially expressed by lymphoid cell lines.

Post-translational modifications:
Tyrosine phosphorylated by LCK.

DISEASE:
Genetic variations in SH2B3 are associated with susceptibility to celiac disease type 13 (CELIAC13)[MIM:612011]; also known as susceptibility to gluten-sensitive enteropathy type 13. Celiac disease is a multifactorial disorder of the small intestine that is influenced by both environmental and genetic factors. It is characterized by malabsorption resulting from inflammatory injury to the mucosa of the small intestine after the ingestion of wheat gluten or related rye and barley proteins. In its classic form, celiac disease is characterized in children by malabsorption and failure to thrive. Genetic variations in SH2B3 are associated with susceptibility to insulin-dependent diabetes mellitus (IDDM) [MIM:222100]; also known as diabetes mellitus type 1. IDDM normally starts in childhood or adolescence and is caused by the body's own immune system which destroys the insulin-producing beta cells in the pancreas.
Classical features are polydipsia, polyphagia and polyuria, due to hyperglycemia-induced osmotic diuresis.

Similarity:
Belongs to the SH2B adapter family.
Contains 1 PH domain.
Contains 1 SH2 domain.

Database links:

Entrez Gene: 10019 Human

Entrez Gene: 16923 Mouse

Entrez Gene: 58838 Rat

Omim: 605093 Human

SwissProt: Q9UQQ2 Human

SwissProt: O09039 Mouse

SwissProt: P50745 Rat

Unigene: 506784 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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