Rabbit Anti-JIP3/FITC Conjugated antibody

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C-jun-amino-terminal kinase-interacting protein 3; FLJ00027; Homolog of Drosophila Sunday driver 2; JIP-3; JIP3_HUMAN; JNK / Stress Activated Protein Kinase Associated Protein 1; JNK Interacting Protein 3; JNK MAP kinase scaffold protein 3; JNK-interactin

Cat:

SL13648R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Chicken,Dog,Cow,Horse,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human JIP3

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

147kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The JNK-interacting proteins (JIPs) are a family of scaffold proteins that mediate JNK signaling by organizing specific components of the MAPK cascade together to form a functional JNK signaling molecule. JIP-3 (JNK-interacting protein 3), also known as JSAP1 or MAPK8IP3 (Mitogen-activated protein kinase 8-interacting protein 3), is a 1,336 amino acid protein that localizes to the cytoplasm and belongs to the JIP family. Expressed in a variety of tissues, including brain and heart, JIP-3 forms homo- or heterooligomeric complexes that can interact with several components of the JNK signaling pathway, thereby functioning as a regulator of kinesin-dependent axonal transport that may also play a role in scaffold formation within neuronal cells. Human JIP-3, which may be phosphorylated upon DNA damage, shares 69% similarity with its mouse counterpart, suggesting a conserved role between species. Multiple isoforms of JIP-3 exist due to alternative splicing events.

Function:
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of vesicle transport, through interations

Subcellular Location:
Cytoplasm.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.

Similarity:
Belongs to the JIP scaffold family.

Database links:

Entrez Gene: 23162 Human

Entrez Gene: 30957 Mouse

Omim: 605431 Human

SwissProt: Q9UPT6 Human

SwissProt: Q9ESN9 Mouse

Unigene: 207763 Human

Unigene: 43081 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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