Rabbit Anti-NSP3/FITC Conjugated antibody

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Cas/HEF1 associated signal transducer; CHAT; FLJ39664; Novel SH2 containing protein 3; Novel SH2-containing protein 3; NSP 3; PRO34088; SH2 domain containing 3C; SH2 domain containing Eph receptor binding protein 1; SH2 domain containing protein

Cat:

SL13657R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Cow,)

Immunogen：

KLH conjugated synthetic peptide derived from human NSP3

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

94kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
Tumor necrosis factor (TNF) is a pleiotropic cytokine whose function is mediated through two distinct cell surface receptors (1,2). These receptors, designated TNF-R1 and TNF-R2, are expressed on most cell types (1,3). The majority of TNF functions are primarily mediated through TNF-R1 (1,4). FAN (for factor associated with neutral sphingomyelinase (N-SMase) activation) is an intermediate protein that interacts with TNF-R1 to initiate TNF signaling events. FAN binds to TNF-R1 at the cytoplasmic NSD (N-SMase activating domain), which results in the initiation of the N-SMase pathway (5). N-SMase has been shown to be involved in TNF-induced Raf-1 activation (6). FAN contains four carboxy-terminal WD-repeat domains which appear to be involved in protein-protein interaction. The FAN WD-repeats may mediate the interaction between FAN and TNF-R1 (5).

Function:
Eph receptor-binding protein which may be a positive regulator of TCR signaling. Binding to BCAR1 is required to induce membrane ruffling and promote EGF-dependent cell migration.

Subcellular Location:
Cytoplasm. Membrane. Associated with the membrane when EGF-stimulated. Found at ruffling membranes.

Tissue Specificity:
Ubiquitously expressed.

Similarity:
Contains 1 Ras-GEF domain.
Contains 1 SH2 domain.

Database links:

Entrez Gene: 10044 Human

Entrez Gene: 27387 Mouse

Omim: 604722 Human

SwissProt: Q8N5H7 Human

SwissProt: Q9QZS8 Mouse

Unigene: 306412 Human

Unigene: 9593 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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