Home
>
Product
>
Antibody
>
Rabbit Anti-TRAF6BP/FITC Conjugated antibody
background:
Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.
Function:
Inhibits TNF-induced apoptosis by mediating the TNFAIP3 anti-apoptotic activity. Degraded by caspase-3-like family proteins upon TNF-induced apoptosis. May also play a role in the pro-inflammatory cytokine IL-1 signaling cascade.
Subunit:
Homooligomer. Interacts with TRAF6 in a IL-1-dependent manner. Interacts with TNFAIP3. Interacts with STARD13. Interacts with the HTLSLV1 protein Tax-1.
Tissue Specificity:
Expressed in all tissues tested.
Post-translational modifications:
Phosphorylated in the SLCterminal region by CHUK/IKKA leading to NF-kappa-B signaling down-regulation.
Database links:
Entrez Gene: 8887 Human
Entrez Gene: 5288 Mouse
Entrez Gene: 246244 Rat
Omim: 605326 Human
SwissProt: Q86VP1 Human
SwissProt: Q3UKC1 Mouse
SwissProt: Q66HA4 Rat
Unigene: 34576 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
|
|