Rabbit Anti-PARD6G/FITC Conjugated antibody

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PAR 6 gamma protein; par 6 partitioning defective 6 homolog gamma; PAR 6G; PAR6D; PAR6gamma; Partitioning defective 6 homolog gamma; PAR6G_HUMAN.

Cat:

SL13696R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Pig,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human PARD6G

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

41kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
PARD6G (partitioning defective 6 homolog gamma) is a 376 amino acid adaptor protein that is involved in cell polarization and asymmetrical cell division processes. PARD6G contains one OPR domain, one PDZ (DHR) domain and one pseudo-CRIB domain. The PDZ and pseudo-CRIB domains are required for interaction with Rho small GTPases. Through its complex formation with PARD3G, PARD6G participates in the linking of GTP-bound Rho small GTPases to atypical protein kinase C (PKC) proteins. This assembly is involved in formation of normal tight junctions at epithelial cell-cell contacts. When atypical PKC and PARD6G are expressed with a constitutively active RAC, the proteins colocalize to the membrane ruffles, which are structures that occur at the leading edge of polarized cells during movement. Though widely expressed, PARD6G is found at highest levels in adult and fetal kidney.

Function:
Adapter protein involved in asymmetrical cell division and cell polarization processes. May play a role in the formation of epithelial tight junctions. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.

Subunit:
Interacts with PARD3 (Probable). Interacts with GTP-bound forms of CDC42, ARHQ/TC10 and RAC1. Interacts with the N-terminal part of PRKCI and PRKCZ.

Subcellular Location:
Cytoplasm. Cell membrane (By similarity). Cell junction, tight junction (By similarity).

Tissue Specificity:
Widely expressed, with a higher expression in fetal and adult kidney.

Similarity:
Belongs to the PAR6 family.
Contains 1 OPR domain.
Contains 1 PDZ (DHR) domain.
Contains 1 pseudo-CRIB domain.

Database links:

Entrez Gene: 84552 Human

Omim: 608976 Human

SwissProt: Q9BYG4 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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