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Rabbit Anti-SIRT2/FITC Conjugated antibody
background:
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene. [provided by RefSeq, Jul 2010]
Function:
NAD-dependent protein deacetylase, which deacetylates the 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton.
Subcellular Location:
Cytoplasm, cytoskeleton. Colocalizes with microtubules.
Tissue Specificity:
Widely expressed. Highly expressed in heart, brain and skeletal muscle, while it is weakly expressed in placenta and lung. Down-regulated in many gliomas suggesting that it may act as a tumor suppressor gene in human gliomas possibly through the regulation of microtubule network.
Post-translational modifications:
Phosphorylated at the G2/M transition of the cell cycle.
Similarity:
Belongs to the sirtuin family.
Contains 1 deacetylase sirtuin-type domain.
Database links:
Entrez Gene: 22933 Human
Omim: 60496 Human
SwissProt: Q8IXJ6 Human
Unigene: 466693 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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