Rabbit Anti-PRELP/FITC Conjugated antibody

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55 kDa leucine rich repeat protein of articular cartilage; MST161; MSTP161; Prelp; PRELP_HUMAN; Prolargin; Prolargin proteoglycan; Proline arginine rich end leucine rich repeat protein; Proline-arginine-rich end leucine-rich repeat protein; Proli

Cat:

SL13707R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Cow,Horse,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human PRELP

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

42kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
PRELP (proline/arginine-rich end leucine-rich repeat protein), also known as Prolargin, MST161, SLRR2A or MSTP161, is a 382 amino acid secreted protein that localizes to the extracellular matrix. Belonging to the Class II subfamily of the small leucine-rich proteoglycan (SLRP) family, PRELP contains twelve LRR (leucine-rich) repeats, which are motifs consisting of 20-29 residues that are present in numerous proteins with diverse functions and provide versatile structural framework for the formation of protein-protein interactions. Highly expressed in cartilage, basement membranes and developing bone, PRELP is considered a glycosaminoglycan (GAG)- and collagen-binding anchor protein that associates with the basement membrane heparan sulfate proteoglycan perlecan. PRELP acts as a linker between the extracellular matrix and the cell surface of proteoglycans and may be partially responsible for Hutchinson-Gilford progeria (HGP), an extremely rare genetic disorder that causes premature, rapid aging shortly after birth.

Function:
May anchor basement membranes to the underlying connective tissue.

Subcellular Location:
Secreted > extracellular space > extracellular matrix.

Tissue Specificity:
Connective tissue.

Similarity:
Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.
Contains 12 LRR (leucine-rich) repeats.

Database links:

Entrez Gene: 5549 Human

Omim: 601914 Human

SwissProt: P51888 Human

Unigene: 632481 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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