background:
This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants.
Function:
Receptor for the CD200/OX2 cell surface glycoprotein. Also binds to HHSLV8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200.
Subcellular Location:
Secreted and Cell membrane.
Tissue Specificity:
Expressed in granulocytes, monocytes, most T cells, neutrophils, basophils and a subset of NK, NKT and B cells (at protein level). Expressed in bone marrow, lymph nodes, spleen, lung, liver, spinal cord, kidney. Expressed in monocyte-derived dendritic and mast cells.
Post-translational modifications:
The mature form of isoform 2 and/or isoform 4 starts at sequence position 27 of the corresponding isoform.
Similarity:
Belongs to the CD200R family.
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like SLVtype (immunoglobulin-like) domain.
Database links:
Entrez Gene: 131450 Human
Omim: 607546 Human
SwissProt: Q8TD46 Human
Unigene: 309158 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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