Rabbit Anti-PCLKC/FITC Conjugated antibody

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FLJ20124; FLJ20383; MGC163154; PC LKC; PC-LKC; Protocadherin LKC; CDHR2_HUMAN.

Cat:

SL13729R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Pig,)

Immunogen：

KLH conjugated synthetic peptide derived from human PCLKC

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

139kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
PCLKC (Protocadherin LKC) belongs to the protocadherin gene family, a subgroup of the cadherin superfamily. It is predominantly expressed in liver, kidney and colon tissues, and has a role in contact inhibition at the lateral surface of epithelial cells. It is a candidate tumor suppressor.

Function:
Role in contact inhibition at the lateral surface of epithelial cells.

Subunit:
Interacts with MAST2.

Subcellular Location:
Apical cell membrane; Single-pass type I membrane protein. Cell junction. Note=Present at the cell junctions and the apical surface of cells. Colocalizes with actin at the microvilli-like structures which protrude from the apical surface.

Tissue Specificity:
Highly expressed in liver, kidney and colon. Moderately expressed in small intestine. Down-regulated in a number of liver and colon cancers.

Similarity:
Contains 9 cadherin domains.

Database links:

Entrez Gene: 54825 Human

SwissProt: Q9BYE9 Human

Unigene: 4205 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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