Rabbit Anti-CDHF14/FITC Conjugated antibody

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Cadherin family member 14; CDHF14; FAT tumor suppressor homolog 4; Fat-like cadherin protein FAT-J; FAT4; FAT4_HUMAN; FATJ; hFat4; Nbla00548; Protocadherin Fat 4.

Cat:

SL13721R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse,Sheep,)

Immunogen：

KLH conjugated synthetic peptide derived from human CDHF14

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

538kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The cadherins represent a family of Ca2+-dependent adhesion molecules that function to mediate cell to cell binding that is critical for the maintenance of structure and morphogenesis. Cadherins contain a large extracellular domain at the N-terminus, which is characterized by a series of five homologous repeats, the most distal of which is thought to be responsible for binding specificity. The relatively short SLCterminal intracellular domain interacts with a variety of cytoplasmic proteins, including beta-catenin, to regulate cadherin function. The cadherin superfamily includes cadherins, protocadherins, desmogleins and desmocollins. FAT4 (FAT tumor suppressor homolog 4), also known as FAT-J, CDHF14 or CDHR11, is a 4,981 amino acid single-pass type I membrane protein that belongs to the protocadherin subfamily of cadherins and localizes to the primary cilia of kidney. Widely expressed, FAT4 contains thirty-four cadherin domains, six EGF-like domains and two laminin G-like domains. FAT4 may function in the regulation of planar cell polarity.

Function:
May function in the regulation of planar cell polarity (By similarity). Cadherins are cell-cell interaction molecules.

Subcellular Location:
Membrane. In the kidney, localizes to primary cilia.

Tissue Specificity:
Widely expressed. Expressed in fetal brain, infant brain, brain tumor and colorectal cancer.

Similarity:
Contains 34 cadherin domains.
Contains 6 EGF-like domains.
Contains 2 laminin G-like domains.

Database links:

Entrez Gene: 79633 Human

SwissProt: Q6V0I7 Human

Unigene: 56645 Human

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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