Rabbit Anti-FAM48A/FITC Conjugated antibody

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SP20H_HUMAN; Transcription factor SPT20 homolog; p38-interacting protein; p38IP.

Cat:

SL13720R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Cow,)

Immunogen：

KLH conjugated synthetic peptide derived from human FAM48A

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

86kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
FAM48A is a 779 amino acid protein that interacts with p38 MAP kinase. Specifically, FAM48A and p38 are required for downregulation of E-cadherin during gastrulation. In adult tissues, FAM48A is highly expressed in testis and moderately expressed in brain and pituitary gland. It is also expressed in several fetal tissues, including lung, brain, thymus and kidney. Expression of FAM48A has been shown to be downregulated in malignant prostate tissues. The gene encoding FAM48A maps to human chromosome 13, which houses over 400 genes and comprises approximately 4% of the human genome. Key tumor suppressor genes on chromosome 13 include the breast cancer susceptibility gene, BRCA2, and the RB1 (retinoblastoma) gene.

Function:
Required for MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) activation during gastrulation. Required for down-regulation of E-cadherin during gastrulation by regulating E-cadherin protein level downstream from NCK-interacting kinase (NIK) and independently of the regulation of transcription by Fgf signaling and Snail (By similarity). Required for starvation-induced ATG9A trafficking during autophagy.

Subcellular Location:
Nucleus.

Tissue Specificity:
Highly expressed in testis, moderately in brain and pituitary gland. Expressed in several fetal tissues, including lung, brain, thymus and kidney. Expression is down-regulated in malignant prostate tissues.

Similarity:
Belongs to the FAM48 family.

Database links:

Entrez Gene: 55578 Human

Entrez Gene: 534126 Cow

Entrez Gene: 56790 Mouse

Entrez Gene: 361946 Rat

Omim: 613417 Human

SwissProt: Q8NEM7 Human

SwissProt: Q7TT00 Mouse

SwissProt: Q66HC7 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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