Rabbit Anti-Claudin 18/FITC Conjugated antibody

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Claudin 18; Claudin-18; CLD18_HUMAN; CLDN18; SFTA5; SFTPJ.

Cat:

SL13750R-FITC

Species Reactivity：

(predicted: Human,Rat,Pig,Rabbit,)

Immunogen：

KLH conjugated synthetic peptide derived from human Claudin 18

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

28kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The Claudin superfamily consists of many structurally related proteins in humans (1). These proteins are important structural and functional components of tight junctions in paracellular transport (1,2). Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues (1). Three classes of proteins are known to localize to tight junctions, including the Claudins, Occludin and Junction adhesion molecule (3). Claudins, which consist of four transmembrane domains and two extracellular loops make up tight junction strands (4). Emerging evidence suggests that the Claudin family of proteins regulates transport through tight junctions via differential discrimination for solute size and charge (5).Claudin expression is often highly restricted to specfic regions of different tissues and may have an important role in transcellular transport through tight junctions (6).

Function:
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.

Subcellular Location:
Cell junction > tight junction. Cell membrane.

Tissue Specificity:
Concentrated at the cell-cell borders of epithelial cells.

Similarity:
Belongs to the claudin family.

Database links:

Entrez Gene: 51208 Human

Entrez Gene: 56492 Mouse

Entrez Gene: 315953 Rat

Omim: 609210 Human

SwissProt: P56856 Human

SwissProt: P56857 Mouse

SwissProt: D3ZLY1 Rat

Unigene: 655324 Human

Unigene: 386784 Mouse

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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