background:
The claudin superfamily consists of structurally related proteins that are important structural and functional components of tight junctions. Claudin-23, also known as CLDN23 or CLDNL, is a 292 amino acid multi-pass membrane protein that localizes to cell junctions and belongs to the claudin family. Expressed in stomach and placenta, as well as in germinal center B-cells, claudin-23 is thought to exhibit calcium-dependent cell-adhesion activity through which it plays an essential role in tight junction-specific obliteration of the intercellular space. Human claudin-23 shares 80% sequence similarity with its mouse counterpart, suggesting a conserved role between species. Overexpression of claudin-23 is associated with colon tumors, implicating claudin-23 as a possible metastasis factor.
Subcellular Location:
Integral membrane protein. Tight junctions
Similarity:
Belongs to the claudin family.
Database links:
Entrez Gene: 137075 Human
Entrez Gene: 71908 Mouse
Omim: 609203 Human
SwissProt: Q96B33 Human
SwissProt: Q9D7D7 Mouse
Unigene: 183617 Human
Unigene: 37817 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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