Rabbit Anti-Smoothelin/FITC Conjugated antibody

Home > Product > Antibody > Rabbit Anti-Smoothelin/FITC Conjugated antibody

FLJ35168; FLJ35365; FLJ35620; FLJ38597; Smoothelin; SMSMO; Smtn; SMTN_HUMAN.

Cat:

SL13740R-FITC

Species Reactivity：

Rat,(predicted: Human,Mouse,Dog,Pig,Cow,Rabbit,Orangutan)

Immunogen：

KLH conjugated synthetic peptide derived from human Smoothelin

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

100kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
The cytoskeletal protein smoothelin is highly conserved among vertebrates and is expressed exclusively by contractile smooth muscle cells where it localizes to the filament network. Smoothelin associates with actin stress fibers but does not interact with desmin. At least two isoforms of smoothelin are produced by alternative splicing. The short isoform lacks amino acids 1–544 at the amino-terminus of the long isoform. The short isoform is expressed in visceral muscle tissue, including intestine and stomach, but not in brain, while the long isoform is expressed in all vascularized organs. In the vascular system, smoothelin expression is limited to large veins and arteries capable of pulsatile contraction. As a marker for the highly differentiated contractile smooth muscle cell, smoothelin expression is useful for studying vascular malformation and injury. The gene encoding human smoothelin maps to chromosome 22q12.2.

Function:
Structural protein of the cytoskeleton.

Subcellular Location:
Cytoplasm > cytoskeleton. Exhibits a filamentous organization.

Tissue Specificity:
Smooth muscle; contractile or vascular (for the long form).

Similarity:
Belongs to the smoothelin family.
Contains 1 CH (calponin-homology) domain.

Database links:

Entrez Gene: 6525 Human

Entrez Gene: 29856 Mouse

Entrez Gene: 289734 Rat

Omim: 602127 Human

SwissProt: P53814 Human

SwissProt: Q921U8 Mouse

Unigene: 149098 Human

Unigene: 188516 Mouse

Unigene: 40766 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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