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Rabbit Anti-Claudin 12/FITC Conjugated antibody
background:
The claudin superfamily consists of many structurally related proteins that are important structural and functional components of tight junctions. Claudin-12, also known as CLDN12, is a 244 amino acid multi-pass membrane protein that is expressed in the brain, duodenum, jejunum, ileum, and colon. Claudin-12 localizes to cell junctions and may be involved in tight junction integrity by regulating hyperammonemia. Ammonia can alter brain capillary endothelial cell gene expression and transporter function. Claudin-12 is upregulated in enterocytes through vitamin D receptors which strongly suggest that claudin-12 forms paracellular Ca(2+) channels in intestinal epithelia and may be critical for vitamin D-dependent calcium homeostasis.
Function:
Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
Subcellular Location:
Cell junction > tight junction. Cell membrane.
Similarity:
Belongs to the claudin family.
Database links:
Entrez Gene: 9069 Human
Omim: 611232 Human
SwissProt: P56749 Human
Unigene: 258576 Human
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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