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Rabbit Anti-TOMM20/FITC Conjugated antibody
background:
The mitochondrial preprotein translocases of the outer membrane (Tom) is a multisubunit protein complex that facilitates the import of nucleus-encoded precursor proteins across the mitochondrial outer membrane (1). The Tom machinery consists of import receptors for the initial binding of cytosolically synthesized preproteins and a general import pore (GIP) for the membrane translocation of various preproteins into the mitochondria (2). The import receptors include Tom20 and Tom22, which form a heteromeric receptor complex that initiates the insertion of newly synthesized proteins into the outer membrane and then directs the precursor protein into the GIP (3,4). In yeast, Tom22 is the essential component of the import receptor complex as it functions as both a receptor for the preproteins and serves as a docking point for both Tom20 and the GIP (5,6). Tom22 directly associates with Tom40, the major component of the GIP, and thereby forms a stable interaction between the two core complexes to facilitate the fluid movement of preproteins into the mitochondria (6,7). The insertion of Tom40 into the Tom machinery requires the initial binding of Tom40 to Tom20 and leads to the efficient incorporation of Tom40 precursors into preexisting Tom complexes (2,8)
Function:
Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore.
Subunit:
Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex).
Subcellular Location:
Mitochondrion outer membrane.
Similarity:
Belongs to the Tom20 family.
Database links:
Entrez Gene: 1964 Human
Entrez Gene: 67952 Mouse
Entrez Gene: 266601 Rat
Omim: 601848 Human
SwissProt: Q15388 Human
SwissProt: Q9DCC8 Mouse
SwissProt: Q62760 Rat
Unigene: 533192 Human
Unigene: 380026 Mouse
Unigene: 6932 Mouse
Unigene: 2143 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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