Rabbit Anti-PSMD12/FITC Conjugated antibody

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26S Proteasome regulatory subunit p55; 26S proteasome non-ATPase regulatory subunit 12; 26S proteasome regulatory subunit p55; 26S proteasome regulatory subunit RPN5; MGC75406; p55; proteasome (prosome, macropain) 26S subunit, non ATPase12; Proteas

Cat:

SL13775R-FITC

Immunogen：

KLH conjugated synthetic peptide derived from human PSMD12

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

52kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
In eukaryotic cells, selective breakdown of cellular proteins is ensured by their ubiquitination and subsequent degradation by the 26S Proteasome. The 26S Proteasome is a protease complex that selectively breaks down proteins that have been modified by polyubiquitin chains. It is made up of two multisubunit complexes: the 20S Proteasome chamber, which serves as the proteolytic core of the complex and two 19S regulatory particles which recognize and unfold ubiquitinated proteins. PSMD12 (proteasome (prosome, macropain) 26S subunit, non-ATPase, 12), also known as p55 or Rpn5, is a 456 amino acid protein belonging to the proteasome subunit p55 family. PSMD12 acts as a regulatory subunit of the 26S proteasome and is a component of the PA700 complex. PSMD12 contains one PCI domain.

Function:
Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.

Similarity:
Belongs to the proteasome subunit p55 family.
Contains 1 PCI domain.

Database links:

Entrez Gene: 5718 Human

Entrez Gene: 66997 Mouse

Entrez Gene: 287772 Rat

Omim: 604450 Human

SwissProt: O00232 Human

SwissProt: Q9D8W5 Mouse

Unigene: 592689 Human

Unigene: 21667 Mouse

Unigene: 15873 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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