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Rabbit Anti-E-selectin/FITC Conjugated antibody
background:
The se-selectin is expressed by cytokine-stimulated endothelial cells. It is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. This gene is present in single copy in the human genome and contains 14 exons spanning about 13 kb of DNA. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis.
Subunit:
Interacts with PSGL1/SELPLG through the sialyl Lewis X epitope. PSGL1 sulfation appears not to be required for this interaction.
Subcellular Location:
Membrane; Single-pass type I membrane protein.
Similarity:
Belongs to the selectin/LECAM family.
Contains 1 SLCtype lectin domain.
Contains 1 EGF-like domain.
Contains 6 Sushi (CCP/SCR) domains.
Database links:
Entrez Gene: 1281 Human
Entrez Gene: 20339 Mouse
Entrez Gene: 25544 Rat
Omim: 131210 Human
SwissProt: P16581 Human
SwissProt: Q00690 Mouse
SwissProt: P98105 Rat
Unigene: 82848 Human
Unigene: 5245 Mouse
Unigene: 10359 Rat
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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