background:
Nidogens are highly conserved proteins present in vertebrate and invertebrate basement membranes. Nidogens connect the Laminin and Collagen IV networks and integrate other proteins into the membrane. In mammals, two Nidogen proteins, Nidogen and Nidogen-2, interact at comparable levels with Collagen I, IV and Perlecan, serving to stabilize basement membranes and playing a major role in embryogenesis. The two isoforms have a similar shape, consisting of three globular domains, and co-localize in vessel walls and other basement membrane zones. Nidogen-2 is a cell adhesion protein glycosylated at nitrogen and oxygen sites, and is widely distributed in basement membranes in heart, placenta, bone and, to a lesser extent, in pancreas, kidney and skeletal muscle.
Function:
Cell adhesion glycoprotein which is widely distributed in basement membranes. Binds to collagens I and IV, to perlecan and to laminin 1. Does not bind fibulins. It probably has a role in cell-extracellular matrix interactions.
Subunit:
Interacts with LAMA2. Interacts with COL13A1.
Subcellular Location:
Secreted, extracellular space, extracellular matrix, basement membrane.
Tissue Specificity:
Heart, placenta and bone. Less in pancreas, kidney and skeletal muscle.
Similarity:
Contains 5 EGF-like domains.
Contains 5 LDL-receptor class B repeats.
Contains 1 NIDO domain.
Contains 1 nidogen G2 beta-barrel domain.
Contains 2 thyroglobulin type-1 domains.
Database links:
Entrez Gene: 342977 Human
Entrez Gene: 244551 Mouse
Entrez Gene: 288909 Rat
Omim: 608229 Human
SwissProt: P60323 Human
SwissProt: Q495E5 Human
SwissProt: P60324 Mouse
Unigene: 127982 Human
Unigene: 216740 Mouse
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
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