Rabbit Anti-CHAD/FITC Conjugated antibody

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Cartilage leucine rich protein; Cartilage leucine-rich protein; Chad; CHAD_HUMAN; Chondroadherin; Chondroadherin proteoglycan; SLRR4A.

Cat:

SL13884R-FITC

Species Reactivity：

(predicted: Human,Mouse,Rat,Dog,Pig,Cow,Horse,)

Immunogen：

KLH conjugated synthetic peptide derived from human CHAD

Format：

Lyophilized or Liquid

Storage instructions：

Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of ant

Buffer：

0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Concentration：

1mg/ml

Clonality：

Polyclonal

Isotype：

IgG

Applications：

ICC=1:50-200IF=1:50-200not yet tested in other applications.optimal dilutions/concentrations should be determined by the end user.

Host：

Rabbit

Calculated MW：

38kDa

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Unit:

Price: $596.00

Product PDFs

Datasheet: Down Datasheet

Other Information
Citations
Protein Attributes
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background:
CHAD is implicated in the adhesion of fibroblasts, osteoblasts and chondrocytes, which is mediated by interactions with Integrin α2/β1. Existing primarily in monomeric form, CHAD is a secreted protein that localizes to the extracellular matrix and belongs to the small leucine-rich proteoglycan (SLRP) family and class IV subfamily. CHADL (Chondroadherin-like protein) is a 762 amino acid protein containing 21 LRR (leucine-rich) repeats, which promote protein-ligand interactions. Chondroadherin, a closely related protein, promotes attachment of chrondocytes, osteoblasts and fibroblasts and also plays an important role in the regulation of chrodrocyte proliferation and growth. CHADL is a secreted protein that is located in the extracellular space. There are two isoforms of CHADL that exist as a result of alternative splicing events.

Function:
Promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha(2)beta(1). May play an important role in the regulation of chondrocyte growth and proliferation.

Subcellular Location:
Secreted; extracellular space; extracellular matrix.

Tissue Specificity:
Present in chondrocytes at all ages.

Similarity:
Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily.
Contains 9 LRR (leucine-rich) repeats.
Contains 1 LRRCT domain.
Contains 1 LRRNT domain.

Database links:

Entrez Gene: 1101 Human

Entrez Gene: 281069 Cow

Entrez Gene: 609296 Dog

Entrez Gene: 12643 Mouse

Entrez Gene: 29195 Rat

Omim: 602178 Human

SwissProt: Q27972 Cow

SwissProt: O15335 Human

SwissProt: O55226 Mouse

SwissProt: O70210 Rat

Unigene: 97220 Human

Unigene: 88523 Mouse

Unigene: 9899 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

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